A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT
J. Clin. Invest. Jennifer L. Gommerman, et al. 112:755 doi:10.1172/JCI18648 [
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Figure 5LTβR-Ig treatment impairs T cell recall responses to PLP
139–151. (
a) On day 7 after immunization with PLP
139–151 in SJL mice, pooled LN cells from control huIgG (diamonds) and LTβR-Ig–treated (circles) mice were isolated, stimulated in vitro with PLP
139–151, and proliferation was measured by
3H-thymidine uptake. (
b) Supernatants from cultures in
a (0 and 10 μg/ml PLP
139–151, white and gray bars, respectively) were collected at 72 hours and measured by ELISA for IFN-γ content. (
c) Proliferation data as in
a for splenocytes isolated on day 59 after immunization. (
d) Supernatants from cultures in
c (0 and 10 μg/ml PLP
139–151) were collected at 72 hours and measured by ELISA for IFN-γ content. The experiment was also performed at day 10 and day 39 with similar results.
