A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT
J. Clin. Invest. Jennifer L. Gommerman, et al. 112:755 doi:10.1172/JCI18648 [
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Figure 4Relapses but not acute disease are prevented by LTβR-Ig treatment in a chronic murine EAE model. SJL mice were treated with control huIgG (diamonds) or LTβR-Ig (circles) 1 day prior to immunization with PLP
139–151 in CFA. Limb paralysis was scored in all phases of the disease and is represented here as the mean score throughout the cohort (
a), and the incidence of relapse was measured beginning on day 20 (
b). The experiment was performed on 32 animals per group and was performed twice with similar results.
