Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent
J. Clin. Invest. Theresa Berndt, et al. 112:785 doi:10.1172/JCI18563 [
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Figure 2Effect of the infusion of sFRP-4 on solute excretion in intact rats. Intact rats were administered sFRP-4 (black bars; group 2) at a dose of 0.3 μg/kg/h or vehicle (white bars; group 1) by intravenous infusion over a period of 2 hours. C
1 indicates equilibration period prior to the infusion of sFRP-4 or vehicle. C
2 indicates experimental period during which sFRP-4 or vehicle was infused. Fractional excretion of inorganic phosphate, sodium, and calcium were measured as described in the text. *
P < 0.05.
