Impaired pancreatic growth, β cell mass, and β cell function in E2F1 ^–/– mice
J. Clin. Invest. Lluis Fajas, et al. 113:1288 doi:10.1172/JCI18555 [Go to this article.]

Figure 3
Glucose tolerance and macroscopic analysis of the pancreas of E2F1^_/_ or E2F1^+/+ mice. (A) IPGTT measuring the levels of glucose and insulin at different times after intraperitoneal injection of glucose in E2F1^+/+ or E2F1^_/_ mice. (B) Glucose and insulin levels upon a meal-tolerance test. E2F1^_/_ or E2F1^+/+ mice were fed ad libitum after an overnight fast. Ninety minutes after beginning the meal, plasma insulin and glucose levels were measured. (C) Morphology of the entire pancreas from E2F1^+/+ or E2F1^_/_ mice demonstrates the decreased size of the E2F1^_/_ pancreas. (D) Relative weight of three representative tissues of E2F1^_/_ or E2F1^+/+ mice. Weights are as a ratio to total body weight. *Statistically significant differences (ANOVA, P < 0.005).