Impaired pancreatic growth, β cell mass, and β cell function in E2F1 ^–/– mice
J. Clin. Invest. Lluis Fajas, et al. 113:1288 doi:10.1172/JCI18555 [Go to this article.]

Figure 1
Insulin sensitivity in E2F1^_/_ mice. (A) Body fat mass, evaluated by DEXA scanning, and free fatty acid and leptin levels in the serum of E2F1^+/+ and E2F1^_/_ mice (six animals per group). Results are the average of three independent experiments. (B) Fasting plasma glucose and insulin in either 12-week-old or 50-week-old E2F1^+/+ and E2F1^_/_ mice. Results are the mean ± SD of 12 mice analyzed per group. The same number of mice were analyzed in subsequent experiments. (C) Glucose clearance after intraperitoneal injection of insulin (0.75 IU/kg) as a measure of insulin sensitivity in E2F1^_/_ and E2F1^+/+ mice. Glucose values are relative to the initial glucose levels. (Dand E) In vitro ¹⁴C-3-O-methylglucose uptake 10 minutes after insulin addition to isolated adipocytes (D) or myocytes (E) from the same amount of tissue from E2F1^+/+ and E2F1^_/_ mice. Results are normalized by the content of DNA. *Statistically significant differences (ANOVA, P < 0.005).