Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function
J. Clin. Invest. Satoshi Takagi, et al. 112:1372 doi:10.1172/JCI18513 [Go to this article.]

Figure 3
Histopathological analysis of the epidermis from Arnt-null mice and WT littermates. (a) H&E staining of the epidermis in the ventral neck and back regions. SC from Arnt-null mice is tightly packed, especially in the ventral neck region. Sunburn cells, indicated by arrows, are observed in the basal layer in Arnt-null mice. The long arrow indicates a magnified sunburn cell in the inset. Gr, granular layer; Sp, spinous layer; B, basal layer. Bar: 20 μm. (b) The expression of keratin 6 is strongly induced in basal cells, especially in the ventral neck region. Arrows indicate the expression of keratin 6 in hair follicles. Bar: 50 μm.