Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function
J. Clin. Invest. Satoshi Takagi, et al. 112:1372 doi:10.1172/JCI18513 [Go to this article.]

Figure 2
Fatal impairment of the epidermal barrier in Arnt-null mice. (a) Newborn mice immediately after birth. The Arnt-null mice did not show any abnormal appearance. (b) Hourly measurements of body weight. The Arnt-null mice lost weight rapidly and finally died within 24 hours. (c) Skin-permeability assay with 0.1% toluidine blue. The ventral neck and perineal regions of the Arnt-null mice were dyed blue.