Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo
J. Clin. Invest. Nobuyuki Shibusawa, et al. 112:588 doi:10.1172/JCI18377 [
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Figure 5Cochlear function and histopathology in TR-β mutant animals. (
a) ABR thresholds for TR-β
GS/GS and TR-β
–/– mice are elevated with respect to TR-β
+/+, but loss is greater in TR-β
–/–. Data from individual 8-week-old animals are shown. (
b) DPOAE thresholds for TR-β
GS/GS and TR-β
–/– mice are elevated with respect to WT; however, TR-β
–/– exhibited a much greater deficit. Data are mean ± SEM. Group sizes were 10, 18, and 14 for TR-β
+/+, TR-β
GS/GS, and TR-β
–/–, respectively. (
c–
e) Photomicrographs of the upper basal turn (cochlear frequency approximately 16 kHz) from WT and TR-β mutant cochleas. Arrows indicate: (
c) tectorial membrane in TR-β
+/+; (
d) misaligned feet of outer pillar cells in TR-β
GS/GS; (
e) collapse of outer supporting cells (unfilled) and loss of spiral ligament fibrocytes in TR-β
–/– (filled). Scale bar in
c applies to all three images. (
f–
h) Basal-turn OHC loss is seen in TR-β
–/– mice. Data from one ear of each genotype are shown. Symbol key in
g applies to all three panels.
