Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo
J. Clin. Invest. Nobuyuki Shibusawa, et al. 112:588 doi:10.1172/JCI18377 [
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Figure 4Selective loss of M-cone and altered S-cone distribution in TR-β
GS/GS and TR-β
–/– mutant mice. The left panels show S opsin immunostaining visualized with red fluorescence. The right panels display M opsin–specific immunostaining labeled with green fluorescence in retina of TR-β
+/+, TR-β
GS/GS, and TR-β
–/– mice. Both superior (dorsal) and inferior (ventral) regions are displayed from each genotype. TR-β
GS/GS and TR-β
–/– mice showed S opsin expression in significantly more dorsal regions of cone photoreceptors compared with TR-β
+/+ mice and had an absence of M opsin expression throughout the retina.
