Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance
J. Clin. Invest. Brian W. Busser, et al. 112:1361 doi:10.1172/JCI18310 [
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Figure 6Loss of B cell tolerance is associated with B7.2 expression on anti-dsDNA B cells. Seven days after cGVHD induction in B6.PL/3H9.KI mice, spleen cells were stained for expression of B7.2, B220, and λ1. Histograms show B7.2 expression on gated B220
+ λ1
+ cells for mice receiving B6 (thin lines) or I-A
b–reactive CD4
+ T cells (thick lines). Representative results of four experiments are shown.