Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance
J. Clin. Invest. Brian W. Busser, et al. 112:1361 doi:10.1172/JCI18310 [Go to this article.]

Figure 1
Proliferation of I-A^b–reactive CD4⁺ T cells in B6 mice. B6 mice were injected (intravenously) with 5 × 10⁶ CFSE-labeled CD4⁺ T cells. After 42 hours, animals were euthanized and spleen cells stained with anti-CD4 and analyzed by flow cytometry. Histograms show the division history of gated live splenic CFSE⁺ CD4⁺ T cells. Percentage of CD4⁺ T cells responding to B6 APCs is shown in the upper-left corner of the histogram. The y axis is at least 100 events for each histogram. Representative results from three independent experiments are shown.