Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans
J. Clin. Invest. Chiara Luberto, et al. 112:1080 doi:10.1172/JCI18309 [
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Figure 5Virulence of
C. neoformans in animal models. (
a) Survival of A/Jcr mice infected with
C. neoformans WT,
GAL7:IPC1,
Δapp1,
IPC1Rec, and
Δapp1Rec strains; average mouse survivals were 14.9 ± 3.31, 25.4 ± 5.52, 21.7 ± 2.11, 18.8 ± 3.2, and 17.1 ± 2.5 days, respectively. The
GAL7:IPC1- and
Δapp1-infected mice lived significantly longer than WT mice (
P = 0.002 and 0.01, respectively). (
b) Survival of Tgε26 mice. Mice infected with the
GAL7:IPC1 strain 10 lived significantly longer than WT-infected mice (20.14 ± 2.95 and 16.21 ± 1.76 days on average, respectively;
P = 0.01), and mice infected with the
Δapp1 strain showed a significantly decreased survival as compared with WT-infected mice (13.5 ± 0.51 versus 16.21 ± 1.76 days, respectively;
P = 0.03). Mice infected with
IPC1Rec and
Δapp1Rec showed average survivals of 17 ± 2.2 and 15.85 ± 1.79 days, respectively, which were not significantly different from the average survival observed in WT-infected mice (
P > 0.05).
