Hyper-IgM syndrome type 4 with a B lymphocyte–intrinsic selective deficiency in Ig class-switch recombination
J. Clin. Invest. Kohsuke Imai, et al. 112:136 doi:10.1172/JCI18161 [Go to this article.]

Figure 5
Generation of SHMs in the VH region of IgM in HIGM4. (a) The frequency of SHMs in the VH region of IgM is normal in HIGM4 patients. SHMs in the VH3-23 region of the IgM were analyzed using cDNA from CD19⁺CD27⁺ B cells from controls (n = 7), HIGM2 patients (n = 9), and HIGM4 patients (n = 6, P2, P5–P9). Horizontal bars indicate the mean values. (b) The pattern of SHMs in the VH region of IgM is normal in HIGM4 patients. Mean percentages of nucleotide changes and targets of SHMs in the VH3-23 region of IgM in controls (n = 7) and HIGM4 patients (n = 6, P2, P5–P9) are shown.