Angiotensin II–accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
J. Clin. Invest. Dennis Bruemmer, et al. 112:1318 doi:10.1172/JCI18141 [Go to this article.]

Figure 6
Expression of CD68, MCP-1, CCR-2, VCAM-1, and the cytokines INF-γ, IL-10, and IL-12 in Ang II–infused mice. ApoE^–/–OPN^+/+, ApoE^–/–OPN^+/–, and ApoE^–/–OPN^–/– mice were infused with vehicle or Ang II for 2 weeks. Tissue mRNA of the thoracic aorta was analyzed for CD68, MCP-1, CCR-2, and VCAM-1 (a) or INF-γ, IL-12, and IL-10 (b) mRNA expression. Data are normalized for GAPDH mRNA expression and are represented as the average mean ± SEM.