Angiotensin II–accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
J. Clin. Invest. Dennis Bruemmer, et al. 112:1318 doi:10.1172/JCI18141 [Go to this article.]

Figure 4
Atherosclerosis in ApoE^–/– mice transplanted with ApoE^–/–OPN^+/+ or ApoE^–/–OPN^–/– bone marrow. ApoE^–/– mice were transplanted with either ApoE^–/–OPN^+/+ or ApoE^–/–OPN^–/– bone marrow and infused with Ang II for 4 weeks. (a) Representative Sudan IV–stained thoracic aorta of each analyzed group. (b) Mean atherosclerotic lesion area of ApoE^–/– mice transplanted with ApoE^–/–OPN^+/+ (black bar) or ApoE^–/–OPN^–/– (white bar) bone marrow. Data are represented as the average mean lesion area for each group and expressed as mean ± SEM. *P < 0.05 versus ApoE^–/– bone marrow-transplanted mice ApoE^–/–OPN^+/+. BMT, bone marrow transplanted.