Angiotensin II–accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
J. Clin. Invest. Dennis Bruemmer, et al. 112:1318 doi:10.1172/JCI18141 [Go to this article.]

Figure 3
Atherosclerosis in non-Ang II–infused 8-month-old male ApoE^–/–OPN^+/+ and ApoE^–/–OPN^–/– mice. (a) En face analysis of aortic atherosclerosis in 8-month-old ApoE^–/–OPN^+/+ and ApoE^–/–OPN^–/– mice on a regular chow diet. (b) Mean atherosclerosis development in the total aorta from ApoE^–/–OPN^+/+ (black bar) and ApoE^–/–OPN^–/– (white bar) mice analyzed as described in Figure 1.