Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis
J. Clin. Invest. Brad E. Morrison, et al. 112:1862 doi:10.1172/JCI18125 [
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Figure 8Effect of NK cell depletion or MCP-1/CCL2 neutralization on lung histology in transiently neutropenic mice with invasive aspergillosis. Representative lung H&E and GMS stains 3 days after inoculation with
A. fumigatus conidia are shown (original magnification ×100). H&E panels in all three groups show areas of intense inflammatory infiltration of leukocytes with some areas of associated necrosis. GMS stains show greater numbers of associated fungal elements in PMN depletion and anti–MCP-1 and PMN and NK depletion groups. PMN depletion indicates RB6-8C5 and PBS; PMN depletion and anti–MCP-1 indicates RB6-8C5–treated mice with MCP-1/CCL2 neutralization; PMN and NK depletion indicates mice treated with RB6-8C5 and NK1.1.
