Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis
J. Clin. Invest. Brad E. Morrison, et al. 112:1862 doi:10.1172/JCI18125 [
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Figure 7Survival after intratracheal
A. fumigatus challenge in neutropenic mice with or without NK cell depletion. (
a) Survival study;
n = 15 for each group. *
P < 0.05. (
b) Lung chitin content and MPO activity on day 3 after intratracheal inoculation with conidia in neutropenic mice. MPO activity is a surrogate for presence of neutrophils in the lung in this model. Data represent mean ± SEM;
n = 6 for each group. PMN depletion indicates mice treated with RB6-8C5 and PBS; PMN and NK depletion indicates mice treated with RB6-8C5 and NK1.1.
