Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis
J. Clin. Invest. Brad E. Morrison, et al. 112:1862 doi:10.1172/JCI18125 [
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Figure 3Effect of MCP-1/CCL2 neutralization on lung leukocyte subsets in transiently neutropenic mice after intratracheal challenge with
A. fumigatus conidia. Cell populations were identified as CD45
+ cells expressing the markers in parentheses. *
P < 0.05 compared with infected mice with PMN depletion at the same time point. Data shown represent mean ± SEM;
n = 4–6 for each group at each time point. Uninfected indicates normal uninfected mice; infected/PBS indicates mice treated with RB6-8C5 and PBS and challenged with intratracheal
A. fumigatus conidia; infected/anti–MCP-1 indicates mice treated with RB6-8C5 and anti–MCP-1/CCL2 mAb and challenged with intratracheal
A. fumigatus conidia.
