Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis
J. Clin. Invest. Brad E. Morrison, et al. 112:1862 doi:10.1172/JCI18125 [
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Figure 2Outcome of invasive aspergillosis in neutropenic mice with or without neutralization of MCP-1/CCL2. (
a) Survival study;
n = 15 for each group. (
b) Lung chitin content after intratracheal
A. fumigatus challenge on day 3 after intratracheal inoculation with conidia. Data represent mean ± SEM of
n = 6 for each group. *
P < 0.05 compared with infected mice with polymorphonuclear (PMN) cell depletion. PMN depletion indicates mice treated with RB6-8C5 and PBS; PMN depletion/MCP-1 neutralization indicates mice treated with RB6-8C5 and anti–MCP-1/CCL2 mAb.
