The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis
J. Clin. Invest. Philip A. Marsden, et al. 112:58 doi:10.1172/JCI18114 [
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Figure 5Fgl2/fibroleukin expression and fibrin deposition in human viral hepatitis B. Liver biopsy from a patient with marked chronic hepatitis B. (
a) Area of necrosis and collapse of parenchyma is shown. The few remaining hepatocytes in this field show ballooning degeneration. Hematoxylin and eosin stain. ×400. (
b) Area of necrosis and collapse on left. Many macrophages are present in the area of collapse as shown by the positive CD68 immunoperoxidase stain. ×400. (
c) Area similar to that in
b, showing positivity of Fgl2/fibroleukin by in situ hybridization in the same distribution of the CD68-positive macrophages. ×200. (
d) Another area of acute necrosis and collapse showing positivity using Fgl2/fibroleukin Ab and immunoperoxidase stain. ×400. (
e) Similar area of necrosis to that in
d. Fibrin deposits by immunoperoxidase staining are shown by arrows. ×400. (
f) Patient with minimal chronic hepatitis B. This micrograph is representative and shows no evidence of hepatocellular necrosis, but a mixed mild inflammatory infiltrate confined to the portal and septal connective tissue. There is no evidence of Fgl2/fibroleukin in the parenchyma or in the areas of fibrosis areas by immunoperoxidase staining for Fgl2/fibroleukin. ×200.
