The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis
J. Clin. Invest. Philip A. Marsden, et al. 112:58 doi:10.1172/JCI18114 [
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Figure 3Fgl2/fibroleukin–deficient mice. (
a) Mortality in MHV-3–infected (1,000 PFU)
Fgl2/fibroleukin–/– mice was significantly blunted compared with
Fgl2/fibroleukin+/+ littermates, with heterozygotes showing an intermediate phenotype (
n = 10 per group). C57Bl/6 and A/J strains represent susceptible and resistant strains, as reported previously. (
b) Mortality is not affected in LPS-treated Fgl2/fibroleukin–deficient mice. The C3H/HeJ strain is known to be LPS hyporesponsive.
