The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis
J. Clin. Invest. Philip A. Marsden, et al. 112:58 doi:10.1172/JCI18114 [Go to this article.]

Figure 2
Fgl2/fibroleukin–deficient mice have hemorrhage at the feto-maternal interface. Zygotes and uterine tissue were examined by light microscopy and immunohistochemistry using a polyclonal anti-Fgl2 Ab. Feto-maternal interface of Fgl2/fibroleukin^+/+ (Fgl-2^+/+) zygotes at pc day 8.5, as assessed by hematoxylin and eosin staining (a) and Fgl2 immunostaining (b). Murine trophectoderm is positive for Fgl2 immunostaining. Fgl2/fibroleukin^–/– (Fgl-2^–/–) zygotes showed moderate to severe hemorrhage at implantation sites, with extravasation of maternal erythrocytes (rbc; arrowhead) between the mural trophectoderm and Reichert’s membrane (arrow) at the antimesometrial pole as assessed by hematoxylin and eosin staining (c) and negative Fgl2 immunostaining (d) (see Methods).