Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease
J. Clin. Invest. Alon Monsonego, et al. 112:415 doi:10.1172/JCI18104 [Go to this article.]

Figure 2
Aβ T cell reactivity is increased in elderly subjects and patients with AD. PBMCs were isolated from adult and elderly healthy subjects and patients with AD as described in Methods. Aβ-induced proliferation was measured after secondary stimulation in the split-well assay. (a) Percentage of positive wells was calculated for each individual as in Figure 1. (b) Average SIs ± SEM were calculated for each group on the basis of the average SIs for each individual (sum of positive SIs [each at least 2.5 with a Δcpm of > 2,000] divided by the number of positive wells). Two-tailed P values were calculated using the alternate Welch t test, assuming Gaussian populations with unequal SDs.