Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8⁺ cell–dependent mechanism
J. Clin. Invest. Kenneth K. Wong, et al. 112:1741 doi:10.1172/JCI18020 [Go to this article.]

Figure 5
Notch ligand transfectants induce prolonged graft survival. (a) C3H/HeJ recipients (H-2^k) were injected intravenously with either untransfected L cells (H-2^k), K^b, A^b, K^b/Dl1, A^b/Dl1, a mixed population of K^b + A^b, or a mixed population of K^b/Dl1 + A^b/Dl1. The dose of K^b-expressing cells was 5 × 10⁶, and the dose of A^b-expressing cells was 10⁶. These animals received heart allografts of H-2^b origin 14 days later. To test antigen specificity of graft-survival prolongation, one group that had been pretreated with K^b/Dl1 and A^b/Dl1 received third-party grafts of BALB/c origin (H-2^d). (b) C3H/He mice were pretreated as above intraperitoneally (i.p.) or intravenously. Data for intravenous injections are from the same animals in both a and b and shown in both for comparative purposes. Heart grafts were assessed daily by palpation for rejection. n = 4–6 in all groups.