Luminal NaCl delivery regulates basolateral PGE₂ release from macula densa cells
J. Clin. Invest. János Peti-Peterdi, et al. 112:76 doi:10.1172/JCI18018 [Go to this article.]

Figure 6
COX-2 (a–c) and mPGES (d and e) immunofluorescence of kidney cortex in control rabbits (a and d) and rabbits fed a low-salt diet (b and e). Number of COX-2–positive cells (c, n = 6 in each group, *P < 0.05 compared with normal salt diet) and mPGES expression in the MD significantly increased in response to the low-salt diet (LS) compared with the normal salt diet (NS). Nuclei are blue. In situ hybridization clearly demonstrated mPGES mRNA expression in MD cells (f).