T cell apoptosis and reactive oxygen species
J. Clin. Invest. David A. Hildeman, et al. 111:575 doi:10.1172/JCI18007 [Go to this article.]

Figure 1
Graph of the kinetics of the T cell response to antigenic stimulation in vivo. Following stimulation with antigen, antigen-specific T cells proliferate vigorously to reach peak numbers during the expansion phase. They then decline in number rapidly, a process referred to as the contraction phase. Importantly, both the peak-expansion phase and the contraction phase can be independently modulated by stimulators of innate immunity (adjuvants) (53, 54).