Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice
J. Clin. Invest. Mahtab Moayeri, et al. 112:670 doi:10.1172/JCI17991 [
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Figure 4Histopathological analysis of LT-treated BALB/cJ bone marrow. (
a) Diaphyseal marrow from PA-treated (48 hours) control. 40× objective. (
b) A mild degree of individual cell death in diaphyseal marrow at 6 hours after LT treatment. 40× objective. (
c) A moderate degree of individual cell death in diaphyseal marrow at 18 hours. 40× objective. (
d) Metaphyseal (right) and epiphyseal (left) marrow in PA-treated (48 hours) control. 10× objective. (
e) Necrosis of metaphyseal marrow (right) with sparing of epiphyseal marrow (left) at 48 hours after LT treatment. 10× objective. (
f) Necrosis of metaphyseal bone marrow at 48 hours. 40× objective. Dosage was 100 μg PA (control) or 100 μg LT.
