Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice
J. Clin. Invest. Mahtab Moayeri, et al. 112:670 doi:10.1172/JCI17991 [
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Figure 3Histopathological analysis of LT-treated BALB/cJ mouse spleen. (
a) Red pulp from PA-injected (48 hours) control. 40× objective. (
b) Individual cell death in red pulp with relative sparing of white pulp at 6 hours after LT treatment. 40× objective. (
c) Advanced necrosis in red pulp at 12 hours. 40× objective. (
d) Hemorrhage in red and white pulp at 18 hours. 20× objective. (
e) Hemorrhage in red and white pulp at 18 hours. 2× objective. (
f) Resolution of cell death with restoration of extramedullary hematopoiesis (EMH) at 48 hours. 40× objective. Dosage was 100 μg PA (control) or 100 μg LT.
