VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
J. Clin. Invest. Yunjuan Sun, et al. 111:1843 doi:10.1172/JCI17977 [
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Figure 5Effects of intraventricular VEGF on the number of BrdU-labeled neurons in DG and SVZ, ipsilateral and contralateral to MCAO, at 3 and 28 days after ischemia. For control, aCSF was administered instead of VEGF. Dotted line, basal level of BrdU labeling in normal, nonischemic rats. Two-way ANOVA showed significant effects of location (F = 26.85,
P < 0.0001) but not treatment (F = 2.48,
P = 0.120) on the number of BrdU-labeled neurons at 3 days after ischemia and of location (F = 22.13,
P < 0.0001) and treatment (F = 27.28,
P < 0.0001) on the number of BrdU-labeled neurons at 28 days after ischemia, but no interaction between location and treatment at 3 days (F = 1.14,
P = 0.340) or 28 days (F = 3.83,
P = 0.014). *
P < 0.05, **
P < 0.01 compared with control on same day at same location (Tukey test;
n = 9). DG-I, ipsilateral dentate gyrus; DG-C, contralateral dentate gyrus; SVZ-I, ipsilateral subventricular zone; SVZ-C, contralateral subventricular zone.
