VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
J. Clin. Invest. Yunjuan Sun, et al. 111:1843 doi:10.1172/JCI17977 [Go to this article.]

Figure 4
Colocalization of BrdU and markers of neuronal lineage in DG (a) and SVZ (b) of the VEGF-treated, postischemic rat brain. Rats underwent MCAO and were treated with intraventricular aCSF (Control) or VEGF and killed 28 days after MCAO. (a and b) Brain sections were immunostained for BrdU (top) or for both BrdU and the neuronal lineage marker NeuroD (a) (bottom) or Dcx (b) (bottom). VEGF treatment increased BrdU labeling in both DG and SVZ, and BrdU labeling colocalized with neuronal lineage markers in both regions. Lines in upper panels of b demarcate the lateral ventricle. Data shown are representative of findings from at least four animals per experiment.