VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
J. Clin. Invest. Yunjuan Sun, et al. 111:1843 doi:10.1172/JCI17977 [Go to this article.]

Figure 2
Quantitative effects of intraventricular VEGF on infarct volume and neurological function after MCAO. Rats were subjected to MCAO and treated with intraventricular aCSF (Control) or VEGF, and infarct volume (a) and neurological grade (b) were determined at the intervals shown. Note that a higher neurological grade in b denotes more severely impaired function. Two-way ANOVA showed significant effects of treatment (Fisher ratio [F] = 68.25, P < 0.0001) and time (F = 9.33, P = 0.001) on infarct volume and of treatment (F = 30.25, P < 0.0001) and time (F = 27.41, P < 0.0001) on neurological grade, but no interaction between treatment and time (F = 0.42, P = 0.741). *P < 0.01 compared with control on same day (Tukey test; n = 3).