PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance
J. Clin. Invest. Sean M. Crosson, et al. 111:1423 doi:10.1172/JCI17975 [Go to this article.]

Figure 6
PTG+/– mice have decreased glucose transport into white fiber muscle and decreased liver glycogen synthesis with a compensatory increase in epididymal adipose glucose transport during an intraperitoneal glucose tolerance test. (a) Male animals 3–4 months of age were fasted overnight for 16 hours and used for in vivo glucose uptake experiments (n = 8 wild-type and 9 PTG+/– animals). Results are reported as mean ± SEM (*P ≤ 0.05). 2-DG, 2-deoxyglucose. (b) The increase in epididymal adipose glucose transport in PTG+/– mice cannot fully compensate for the decreases in quadriceps glucose transport and liver glycogen synthesis. Results from part a are corrected for the average protein mass of each tissue to give relative values of glucose uptake during the intraperitoneal glucose tolerance test. Results are reported as mean ± SEM (*P ≤ 0.05).