Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
J. Clin. Invest. Nives Zimmermann, et al. 111:1863 doi:10.1172/JCI17912 [Go to this article.]

Figure 2
Expression of L-arginine metabolizing enzymes. Expression of arginase I (a), arginase II (b), CAT2 (c), and iNOS (e) in ovalbumin (OVA) and A. fumigatus (Asp)-challenged mice as measured by gene chip analysis is shown. The average difference for the hybridization signal after saline (gray bar) and allergen (black bar) challenge is depicted (n = 2 for Aspergillus control group and n = 3 for OVA control group and OVA and Aspergillus experimental groups). Error bars represent the SD. A schematic representation of the L-arginine metabolism pathway is shown in d. Genes not present on the chip are depicted with a white box, genes present but not significantly increased with a gray box, and significantly increased genes with a black box. Abbreviations are AL, argininosuccinate lyase; AS, argininosuccinate synthetase; ODC, ornithine decarboxylase; and OAT, ornithine aminotransferase.