Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human
J. Clin. Invest. Kobra Haghighi, et al. 111:869 doi:10.1172/JCI17892 [Go to this article.]

Figure 3
Effect of wild-type and homozygous or heterozygous mutant PLN-L39stop on the Ca²⁺ affinity of SERCA2a. HEK-293 cells were cotransfected with wild-type, homozygous, or heterozygous mutant PLN cDNA and SERCA2a cDNA, and the rates of Ca²⁺ uptake were measured. The results are representative of two nearly identical and independent experiments. V_max, maximum velocity of Ca²⁺ uptake.