Bone marrow stem cells contribute to repair of the ischemically injured renal tubule
J. Clin. Invest. Sujata Kale, et al. 112:42 doi:10.1172/JCI17856 [Go to this article.]

Figure 5
Bone marrow–derived cells express the renal proximal tubule–specific marker megalin. Sections from kidneys of mice that underwent 25 minutes of ischemia 16 weeks after BMT, followed by 1 week of reflow, were double stained with X-gal (a) and the proximal tubule–specific marker megalin (b). Tubules from the outer medulla that contain cells derived from the bone marrow of the Rosa26 mouse (a, arrow) express megalin on their apical surface (b, arrow), with the merged image showing double staining of the same cell (c, arrows). Two other S3 tubules are shown that express megalin (b, arrowheads) but are not β-galactosidase positive (a, arrowheads). Megalin and β-galactosidase–negative tubules seen faintly in the background represent medullary thick ascending limbs and collecting ducts.