Bone marrow stem cells contribute to repair of the ischemically injured renal tubule
J. Clin. Invest. Sujata Kale, et al. 112:42 doi:10.1172/JCI17856 [
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Figure 2Mouse model of I/R. Low-magnification (×4;
a,
c, and
e) and high-magnification (×40;
b,
d, and
f) views of H&E-stained sections from control kidneys (
a and
b) and kidneys 24 hours after warm I/R for 25 minutes (
c and
d) and 30 minutes (
e and
f). Twenty-five minutes of warm ischemia results in swelling of the cortical and inner medullary tubular cells and selective necrosis of the S3 segment of the proximal tubule in the outer medulla (
c and
d, arrows), whereas 30 minutes of warm ischemia causes more extensive necrosis of tubules in the outer medulla as well as necrosis of proximal tubules in the cortex (
e, arrowhead; and
f).
