Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity
J. Clin. Invest. Shu-Ching Shih, et al. 112:50 doi:10.1172/JCI17808 [Go to this article.]

Figure 2
Real-time RT-PCR quantification of VEGFR-1 and VEGFR-2 mRNA during retinal vascular development. Copy numbers of VEGFR-1 and VEGFR-2 mRNA/10⁶ copies cyclophilin A control mRNA at specific timepoints were measured. (a) VEGFR-1 mRNA expression increases linearly with retinal vascular development; expression is 60-fold higher at P26 than at P3. (b) VEGFR-2 mRNA expression decreases modestly (<15%) during retinal vessel development. The ratio of VEGFR-2 mRNA to VEGFR-1 mRNA expression ranges from 200-fold at P3 to twofold at P26.