Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity
J. Clin. Invest. Shu-Ching Shih, et al. 112:50 doi:10.1172/JCI17808 [
Go to this article.]
Figure 1P5 retinal whole-mount in situ hybridization of VEGF-A, VEGFR-1, and VEGFR-2 mRNA’s. (
a) VEGF-A mRNA (pink) is detected anterior to the growing vessel front as outlined by (
b) FITC-dextran perfusion of vessels (yellow green). Posterior to the vessel front, VEGF-A expression is suppressed (light yellow). (
c) VEGFR-1 mRNA (pink) is detected in the central retina but is not seen at the anterior edge of vessels as outlined by (
d) FITC-dextran perfusion of vessels (yellow). (
e) VEGFR-2 mRNA (pink) is detected in the entire retina and does not correspond to the vessels (
f) outlined in yellow.
