The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
J. Clin. Invest. Aimin Xu, et al. 112:91 doi:10.1172/JCI17797 [Go to this article.]

Figure 5
Adiponectin treatment decreases alcohol-induced elevation of hepatic TNF-α expression and its plasma concentrations. (a) Total RNA from livers of mice treated with LC diet, LE diet, or LE + Ad diet was extracted and subjected to Northern blot analysis. (b) The results from a were quantified by PhosphorImaging (n = 5). All RNA levels are expressed relative to untreated LC pair-fed controls, after being normalized against the abundance of 18S RNA. (c) Plasma concentrations of TNF-α as measured at necropsy (n = 5). **P < 0.01 for LE + Ad–treated mice versus mice receiving LE diet alone.