The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
J. Clin. Invest. Aimin Xu, et al. 112:91 doi:10.1172/JCI17797 [
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Figure 2Effects of adiponectin treatment on food intake, body weight gains, and circulating levels of glucose and insulin. (
a) Serum adiponectin levels in mice fed with LC diet, LE diet, or LE diet plus adiponectin infusion (LE + Ad), as described in the text (
n = 5). Serum samples were collected at different times following adiponectin treatment. (
b) Food intake in LE diet mice treated with or without adiponectin (
n = 6). (
c) Average daily body weight gains over 2 weeks of adiponectin treatment (
n = 6). (
d) Fasting glucose levels over adiponectin treatment period (
n = 6). (
e) Fasting plasma insulin levels over adiponectin treatment period (
n = 6). Note that adiponectin and alcohol treatment also have no obvious effects on plasma levels of insulin and glucose in the fed state (data not shown). *
P < 0.001 for adiponectin-treated group versus other two groups.