Tetrahydrobiopterin-dependent preservation of nitric oxide–mediated endothelial function in diabetes by targeted transgenic GTP–cyclohydrolase I overexpression
J. Clin. Invest. Nicholas J. Alp, et al. 112:725 doi:10.1172/JCI17786 [
Go to this article.]
Figure 4Arginine-to-citrulline conversion as a measure of eNOS activity. (
a) Citrulline production was increased twofold in GCH-Tg as compared with WT aortas stimulated with Ca ionophore for 90 minutes (*
P = 0.012,
n = 5–6). (
b) Basal citrulline production was increased in GCH-Tg as compared with WT lung protein homogenate (*
P < 0.05,
n = 3).
