DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response
J. Clin. Invest. Avishai Mimran, et al. 113:924 doi:10.1172/JCI17772 [Go to this article.]

Figure 9
The antiergotypic T cell phenotypes in protected rats. Twenty-two days after AA induction, CD4⁺, CD8⁺, CD8⁺TCRα/β⁺, and TCRγ/δ⁺ T cells were purified from DLN cells taken from rats protected by the CD25 DNA vaccine. Equal numbers of the purified T cell populations were measured for their proliferative responses to activated irradiated syngeneic T cells at different stimulator cell concentrations. Proliferative responses are presented as the change in counts per minute (Δ cpm) ± SEM of quadruplicate cultures. *P < 0.02 compared with the purified CD4⁺ proliferative response; ^#P < 0.01 compared to the response of the CD8⁺TCRα/β⁺ T cells.