Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice
J. Clin. Invest. Shoshana Yakar, et al. 113:96 doi:10.1172/JCI17763 [
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Figure 5Inactivation of insulin action in the LID mice is restored by introduction of GHa (LID + GHa mice). (
a) A Western blot analysis of insulin-induced phosphorylation of the IR (
b)
, IRS-1 (
c), and AKT (
d) in muscle. The levels of phosphorylation signals (P) are normalized to total immunoreactivity of IR, IGF-1R, or IRS-1 of
n = 4 in each group. (*
P < 0.05 compared with unstimulated samples.) AU, arbitrary units.
