In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
J. Clin. Invest. Bruno B. Bordier, et al. 112:407 doi:10.1172/JCI17704 [Go to this article.]

Figure 2
HDV viremia following hydrodynamic transfection of HBV transgenic mice. (a) After hydrodynamic transfection, mice sera were tested for HDV genomic RNA by RT-PCR. Ethidium bromide gel of sera from HBV-transgenic mice transfected with vector alone assayed at day 2 (lane 1) and day 7 (lane 2); sera from three transgenic mice transfected with pCMV·HDVIII(+) and pGEM4ayw.2× assayed at day 2 (lanes 3, 5, and 7) and at day 7 (lanes 4, 6, and 8); sera from a nontransgenic mouse transfected with pCMV·HDVIII(+) and assayed at day 2 (lane 9) and day 7 (lane 10). (b) Aliquots of day-7 sera from mice as analyzed in lanes 4, 6, and 8 of a were banded in a CsCl gradient, and fractions were assayed for HDV RNA by quantitative RT-PCR (filled circles) and CsCl density by refractometry (gray line).