Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia
J. Clin. Invest. Aurélie Trenado, et al. 112:1688 doi:10.1172/JCI17702 [
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Figure 5GVL/GVT effects after control of GVHD by sTreg’s. (
a) A20 leukemic cells were injected into irradiated mice at time of BMT. Results are presented as a Kaplan-Meier survival curve for mice receiving BM cells alone (dashed line, open squares,
n = 5), BM cells supplemented with 0.5 × 10
6 conventional T cells (open circles,
n = 5), in addition to 0.5 × 10
6 sTreg’s (filled squares,
n = 5).
P < 0.05 between the last two groups. GVL effect is also evaluated by the presence of A20 cells in the blood of mice detected by the coexpression of B220 and H-2K
d Ag, and also by their large size. (
b) A similar experiment was reproduced using P815 cells. Results are presented as a Kaplan-Meier survival curve for mice receiving BM cells alone (dashed line, open squares,
n = 5), or BM cells supplemented with 10 × 10
6 conventional T cells (open circles,
n = 5), in addition to 10 × 10
6 sTreg’s (filled squares,
n = 5). Because of severe morbidity due to the presence of tumor in all mice of the experimental group, the experiment was stopped at day 35.
