Recipient-type specific CD4⁺CD25⁺ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia
J. Clin. Invest. Aurélie Trenado, et al. 112:1688 doi:10.1172/JCI17702 [Go to this article.]

Figure 2
Regulation of GVHD by sTreg’s is associated with good immune reconstitution. Immune reconstitution was evaluated 45 days after transplantation in the spleen of mice grafted as described in Figure 1. Total splenocytes were counted and stained with appropriate mAb’s. The number of B220⁺, CD3⁺, CD4⁺, and CD8⁺ cells was evaluated after analysis by flow cytometry for BM control mice (white bars; n = 3), GVHD control mice (black bars; n = 4), mice receiving sTreg’s (dark gray bars; n = 5), or irTreg’s (light gray bars; n = 5). Histograms indicate the mean number ± SEM of cells for each group. P < 0.05 between all groups and for all cell populations except for BM alone versus irTreg’s for CD8⁺ cells.