Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
J. Clin. Invest. Mitsutaka Yamamoto, et al. 112:1395 doi:10.1172/JCI17700 [Go to this article.]

Figure 4
The effect of antioxidant treatment on base-line cardiac hypertrophy in Tg-DN-Trx1 mice. Tg-DN-Trx1 mice and NTg littermates were treated with an intraperitoneal injection of MPG (100 mg/kg/d) or saline (vehicle) for 4 weeks. LVW/BW (a) and LVW/TL (b) were determined. (c) LV myocardial sections obtained from NTg mice (left) and Tg-DN-Trx1 mice treated with saline (center) or MPG (right) were subjected to immunostaining with 8-OHdG.