JunD protects against chronic kidney disease by regulating paracrine mitogens
J. Clin. Invest. Evangéline Pillebout, et al. 112:843 doi:10.1172/JCI17647 [
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Figure 1Accelerated renal lesion development in the absence of JunD. Morphology and lesion scores of remnant kidneys from
JunD+/+ (white bars) and
JunD–/– (black bars) mice 60 days after nephron reduction (Nx). Renal lesions were graded according to established methodology in randomly selected microscopic fields of the cortex. (
a) Glomerular lesions, ×400. (
b) Tubular lesions, ×200. (
c) Interstitial fibrosis, ×200. (
d) Interstitial mononuclear cell infiltration, ×200. Results represent mean ± SEM;
n = 6.
#P < 0.05,
##P < 0.01,
JunD–/– versus
JunD+/+ by Mann-Whitney test.
