Glucokinase and IRS-2 are required for compensatory β cell hyperplasia in response to high-fat diet–induced insulin resistance
J. Clin. Invest. Yasuo Terauchi, et al. 117:246 doi:10.1172/JCI17645 [
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Figure 5Insufficient β cell hyperplasia in
Irs2+/– mice on the HF diet.
(
A–
C) Body weight (
A), fasting blood glucose (
B), and serum insulin (
C) values of wild-type and
Irs2+/– mice after 10 weeks on standard chow or HF diet (
n = 5–8). (
D) Insulin tolerance in wild-type and
Irs2+/– mice after 10 weeks on standard chow or HF diet (
n = 4–8). (
E and
F) Area of β cells in each islet (
E) and maximum islet diameter (
F) in wild-type and
Irs2+/– mice after 10 weeks on standard chow or HF diet. We examined 100–150 islets from 3 animals per group. Values represent mean ± SEM. *
P < 0.05; **
P < 0.01.
